Active Cerebrospinal Fluid Exchange System for Treatment of Pyogenic Ventriculitis

ABSTRACT BACKGROUND Despite recent advances in antibiotic treatment, pyogenic ventricular brain infections are still associated with adverse clinical outcome 80% of affected patients and mortality rates approaching 60%. The limitation penetration into the cerebrospinal fluid (CSF) challenges treatment. Intrathecal treatment remains an option for adjunctive therapy to intravenous (iv) antibiotics when iv fails sterilize CFS. Current options do not allow changing CSF composition without adversely affecting intracranial pressure (ICP) power hydrogen (pH). OBJECTIVE To investigate if exchange has impact on ventriculitis patients. METHODS We report 2 cases treated a new active system that consists dual-lumen catheter facilitate irrigation drainage coupled intelligent digital pump. RESULTS This technique allowed us change antibiotic-consisted fluid. resulted ability directly modify concentration targeted CSF, while simultaneously removing bacterial mass harming tissue controlling ICP pH. CONCLUSION Our reported experience shows purulent caused by healthcare-associated or meningitis is now possible also Actively pus altering this manner had infection penetration. Further needed confirm our algorithm correctly tailored assist clinicians reliably treating catastrophic condition.